Latest Posts
News, insights, and updates from RootPath.
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Combinatorial CDR Shuffling: Maximize Your VHH Search Space
Computational design and initial screening of VHH libraries often yield hundreds of candidates, each carrying distinct CDR1, CDR2 and CDR3 sequences on a shared framework. Recombining these CDRs could unlock ultra-performing binders – but building the combinatorial pool with defined junctions has always been non-trivial. Here’s how RootPath’s VHH CDR Shuffler™ turns three lists of CDR sequences into a uniform, high-fidelity combinatorial DNA pool in as few as 5 days.
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